Bare bones 3 column CSS layout

You can put your content here, under the space for a header, or you can re-arrange the divs in the html to put your right or left column first.

This is a good place to pop nice optimized text into, especially if your #content div is full of images and little text. I like to put an 'editors note' here: Just an excuse to squeeze optimized copy into the html flow without bothering the user ;-)

Links, come last, presuming your 'header' has a 'main sections' navigation with regular text links this is just fine for SE's and magic for optimization.